Disbiose intestinal em pacientes com acne vulgar: Mecanismos fisiopatológicos e abordagens terapêuticas

Abstract

INTRODUCTION: Acne vulgaris is a chronic inflammatory dermatosis that affects quality of life. Although the gut microbiota balances the gut-skin axis, dysbiosis induces a pro-inflammatory state that triggers the disease. OBJECTIVE: The objective of this review is to analyze published scientific studies on the mechanisms of the gut microbiota that influence acne and therapeutic strategies. METHODOLOGY: The research was conducted through an integrative literature review of recent clinical studies and reviews. RESULTS: The results point out that intestinal dysbiosis compromises the gut barrier and increases permeability. This allows the translocation of endotoxins and metabolites into the bloodstream, which promotes subclinical inflammation, worsening acne lesions. However, probiotics and omega-3 reverse this condition and restore eubiosis. FINAL CONSIDERATIONS: It is concluded that gut dysregulation is crucial in acne. Clinical management should include dietary interventions and microbiota modulation to restore the gut-skin axis and achieve sustainable results.