Reposicionamento de fármacos na paracoccidioidomicose

Abstract

Paracoccidioides spp. is a thermimorphic fungus causing a systemic mycosis known as paracoccidoidomycosis. Basically, this disease has a worldwide incidence with the highest infection rates in South American countries, where Brazil stands out, reaching 80% of cases. In addition, it is known that the treatment of the disease is very limited, since the vast majority of infected patients use antifungals with low efficacy for long periods. Therefore, it is extremely important to find alternative treatments for this disease. Thus, the objective of this work is to provide a repositioning of the drug for a better treatment of paracoccidioidomycosis. For the repositioning / drugstore analyzes, bioinformatics tools were used, available online, to identify and characterize proteins unique to the fungus. Subsequently, with the aid of specific databases and computational algorithms, verify molecules targeting these proteins. Thus, 4 enzymes unique to Paracoccidioides spp. present in methylcitrate and glyoxylate cycles. At the pharmacological level, 13 experimental molecules and 2 already approved and validated on the market were found. Therefore, with the repositioning and drug addiction analyzes, new molecules were found that can be precursors in the treatment of paracoccidoidomycosis.