Estudo do prognóstico do carcinoma de mama triplo negativo e associações com genes brca1 e brca2 – uma revisão integrativa

Abstract

INTRODUCTION: triple negative breast câncer has the basal subtype, affects Young women under 40 years of age, and has te worst prognosis. It has this name because It has negativity for the three types of receptors: strogen, progesterone and HER2. In this study, we Will correlate CMTN to mutations in the BRCA 1 and BRCA 2 genes. Mutations in these tumor supressor genes are autosomal inherited. The need to emphasize the study on the CMTN is no effective ttreatmen. OBJECTIVES: to carry out a survey of the main characteristics of triple negative breast cancer. METHODOLOGY: the study is a literature review, articles were consulted from the year 2005 – in the databases SciELO (Scientific Electronic library online), INCA (National Cancer Institute), Academic Google and CAPS Journals (Coordination for Improvement of Higher Education Personnel ), in the period from 2005 to 2020, whose study is the diagnosis and prognosis of triple negative carcinoma. This review inclued original articles, conducted in different parts of the word, relating triple negative breast cancer and is risk factors, including association with mutations in the BRCA 1 and BRCA 2 genes. RESULTS: BRCA 1 and BRCA 2 are genes that produce proteins with the same names, these proteins are tumor suppressors responsible for repairing DNA damage, mutations in these genes are associated with the development of CMTN mainly in women under 40 years. Results show that the CMTN has a more aggressive profile regardless of the clinical factores that conclude the prognosis, which leads to a higher mortality rate. CONCLUSION: The study concludes that patients with triple negative breat cancer have a more aggressive tumor profile. Current studies demonstraste the need to create New techniques to improve knowledge about CMTN and the early diagnosis of this tumor, thus facilianting a better prognosis.