Avaliação da toxicidade aguda e subaguda do vegetal lafoensia pacari a. St.-hil

Abstract

The popular use, and even the traditional not sufficient to validate ethically medicinal plants as effective and safe medicines. Accordingly, medicinal plants are no different from any other synthetic xenobiotics and their advocating or official permission of his drug use, should be based on experimental evidence corroborative of the risks to which they expose those who use outweighed by benefits may arise. This time, the objective was to evaluate the plant species Lafoensia pacari (pacari), regarding their acute toxicological effects, in order to classify it according to the criteria of the globalized harmonized system (GHS) of OECD 423, and information about the properties toxic of extract acuoso of L. Pacari (EAP) of potential risks to health resulting from repeated dosing and daily for a period of 30 days according to OECD guidelines 407. The experiments were conducted in laboratory animals (rats and Swiss mice), which were anesthetized at the end of the experiments, and blood collected for conducting biochemical and haematological subsequently euthanized by cervical dislocation and necropsied macroscopic. As a result, the EAP, the acute toxicity test showed no signs of intoxication and even physiological changes, with LD50 (median lethal dose) estimated greater than 2000 mg / kg (GHS class 5 OECD). In subacute toxicity testing, doses of 100 and 200 mg / kg produced no EAP dose-dependent significant alterations in physiological and laboratory parameters or macroscopic bodies. However, chronic use of the plant L. pacari deserves further study.