Efeitos adversos causados pelo uso indiscriminado de anti- inflamatórios não esteroidais em caes e gatos revisão de literatura

Abstract

This study aims to review the main adverse effects associated with the indiscriminate use of nonsteroidal anti-inflammatory drugs (NSAIDs) in dogs and cats, as well as their impacts on the gastrointestinal, renal, and hematological systems. The methodology consists of a descriptive and qualitative bibliographic review, involving the collection and analysis of scientific articles, books, and veterinary manuals focused on pharmacology, with emphasis on NSAIDs, their mechanisms of action, and their toxic effects on the animal organism. The materials used include online bibliographic databases and specialized national and international literature. It was demonstrated that although NSAIDs present analgesic, antipyretic, and anti-inflammatory efficacy, their indiscriminate use without proper guidance results in intoxication and an increase in adverse effects, such as gastrointestinal alterations, nephrotoxicity, and decreased platelet aggregation capacity. It was also observed that COX-2 selectivity reduces some side effects, but does not completely eliminate them. It is concluded that veterinary supervision is essential to minimize complications and ensure greater patient safety.