Potencial da engenharia tecidual na regeneração pulpar: Revisão de literatura

Abstract

INTRODUCTION: Regenerative endodontics has emerged as a promising alternative to conventional root canal treatments by proposing the restoration of pulp vitality through tissue engineering. This approach aims to promote the formation of new biological tissue that replaces the lost pulp, restoring the functionality and longevity of the tooth. *OBJECTIVE:* To analyze the application of tissue engineering in regenerative endodontics, focusing on biological principles, current clinical approaches, and future perspectives for pulp neoformation. *METHODOLOGY:* This is a narrative literature review with a qualitative approach, based exclusively on real and updated scientific articles from the PubMed database, selected according to relevance, methodological rigor, and clinical applicability. RESULTS:The analysis of the selected studies highlighted the importance of tissue engineering components — mesenchymal stem cells, bioactive scaffolds, and molecular signals — for the success of pulp regeneration. Current clinical protocols have evolved with the incorporation of advanced biomaterials, platelet concentrates, and emerging technologies such as bioprinting and virtual simulation. FINAL CONSIDERATIONS: Tissue engineering applied to endodontics represents an innovative and biologically integrated tool to promote pulp neoformation. Despite recent advances, the standardization of clinical protocols and long-term validation are still necessary to consolidate this approach in routine endodontic practice.