Atuação do farmacêutico clínico na prevenção da resistência antimicrobiana em ambientes hospitalares: uma revisão bibliográfica

Abstract

OBJECTIVES: To analyze how the clinical pharmacist's role contributes to the prevention of antimicrobial resistance and optimization of antimicrobial use. METHODOLOGY: An integrative, qualitative review was conducted, also using SciELO, PubMed/MEDLINE, LILACS, and BVS, between June and October 2025, including articles from 2017 to 2025, in Portuguese, English, or Spanish, on the role of the clinical pharmacist. RESULTS: A 20–40% reduction in antibiotic consumption, an increase of up to 35% in adherence to protocols, a 30% reduction in infections by multidrug-resistant microorganisms, and a positive impact on patient safety and multiprofessional integration were observed. Challenges include variability in protocol implementation and the need for greater training. CONCLUSION: Despite the positive results, limitations and gaps in Brazilian hospitals restrict generalization. The pharmacist's role impacts DDD and DOT and is associated with safety. The clinical pharmacist is essential for the rational use of antimicrobials and the prevention of adverse drug reactions (ADRs), requiring the strengthening of protocols and training.