Aplicação terapêutica da toxina botulínica tipo a no tratamento da enxaqueca crônica

Abstract

INTRODUCTION: Chronic migraine is a debilitating neurological condition that significantly compromises patients' quality of life. Given the need for effective and safe therapeutic alternatives, botulinum toxin type A (BoNT-A) has emerged as a promising option in the preventive treatment of the disease. OBJECTIVES: This study aims to analyze the therapeutic application of BoNT-A in chronic migraine, addressing its efficacy, safety, and mechanisms of action. METHODOLOGY: The research was conducted through a literature review of recent clinical studies and systematic reviews. RESULTS: The results indicate that BoNT-A significantly reduces the frequency and intensity of attacks, and is clinically well-tolerated, with mild and transient adverse effects. Its mechanism of action involves inhibiting the release of neurotransmitters and neuropeptides related to pain. CONSIDERATIONS: It can be concluded that botulinum toxin type A is an effective and well-tolerated option for treating chronic migraine, especially in cases resistant to traditional therapies.