Canibalismo celular em lesões de células gigantes da cavidade oral

Abstract

INTRODUCTION: The Central Giant Cell Granuloma (CGCG) is a benign intraosseous lesion, of unknown etiology, that usually occurs in the mandible. Clinical and pathological studies are still looking for possible histological markers to help determine their biological behavior and establish criteria for the diagnosis of its variants, but the results are controversial. AIM: to compare cell cannibalism in aggressive and non-aggressive CGCG. METHODOLOGY: This is an observational cross-sectional study with patients with CGCG conducted that evaluated clinical-demographic and image data, and quantification of cellular cannibalism in multinucleated giant cells. RESULTS: Thirty-three cases of CGCG were evaluated, 10 cases were classified as the aggressive variant and 23 non-aggressive. Female patients were more affected in both variants and the mandible was the most affected site. Cellular cannibalism was observed in the multinucleated giant cells of all investigated cases. CONCLUSION: It is suggested that the density of cellular cannibalism in relation to the density of giant cells per mm2 is higher in aggressive CGCG, when compared to non-aggressive lesions.